Abstract Background Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered.This could lead to imprecise estimates of the target PK parameters, a
Abstract Background Patients with cirrhosis often undergo invasive procedures both for management of complications of their advanced liver disease, including treatment for hepatocellular carcinoma, as well as underlying comorbidities.Despite a current understanding that most patients with cirrhosis are in a rebalanced haemostatic state (despite abn
Introduction In determining the evapotranspiration (ET) of a crop species, factors such as type, crop density, growth stage, climate of the region, physicochemical characteristics and soil fertility, have a significant effect.Therefore, it has a significant complexity.In recent years, new technologies are used to estimate ET, such as surface energy
Ancient trees present structural and functional characteristics fundamental for sustaining complex and unique assemblages of species.They are a resource globally threatened by both intensive land uses and lack of recruitment.Their disappearance would involve not only the loss of majestic organisms with high intrinsic value, but may also result in t